Table 1.

Measurements.

Outcome and variable				Time pointa		Description
Primary outcomes
	Feasibility
		Attrition	T2		Attrition is measured by the number of patients and caregivers who drop out before completing the intervention. We will consider the intervention to have low attrition if >80% dyads remain enrolled.
		Adherence	T2		Adherence is measured by the number of modules completed for dyads. It is determined by high adherence if dyads complete >80% of the modules.
	Acceptability
		Satisfaction	T2		Participant satisfaction with CRCweb is assessed by the 8-item Client Satisfaction Questionnaire (Cronbach α=.93; 8-item; 4-point Likert) among patients and caregivers at the end of the intervention.
Secondary outcomesb
	Intervention effect
		Psychoneurological symptoms	T1, T2		Fatigue: 20-item Multidimensional Fatigue Inventory. A cutoff score of ≥43.5 indicates moderate-to-severe fatigue. Depression: 8-item Patient Health Questionnaire. A cutoff score of ≥10 indicates clinically significant depression. Anxiety: Spielberger State Anxiety Inventories. A cutoff score of >32.2 indicates high levels of state anxiety. Sleep disturbance: Pittsburgh Sleep Quality Index (PSQI). PSQI score of ≥5 indicates a significant level of sleep disturbance. Cognitive dysfunction: Attentional Function Index (AFI). AFI score of <5 indicates a significant level of cognitive dysfunction. Pain: Brief Pain Inventory. A cutoff score of ≥4 indicates moderate to severe pain.
		Quality of life	T1, T2		The Short Form-12 consists of 12 questions about physical and mental health as well as overall health status. It is scored into 2 components: physical component score (PCS) and mental component score (MCS). Higher PCS and MCS scores indicate a better quality of life.

^aT1: before intervention, at baseline; T2: after intervention.

^bThe details for the measures can be found in Multimedia Appendix 1.