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. 2023 Jul 10;14:1222983. doi: 10.3389/fphys.2023.1222983

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Copyright © 2023 Hatem, Poussereau, Gachenot, Pérès, Bouyer and Egée.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dooku1 dose-response curve. (A) Variations in membrane potential after addition of Dooku1 at different concentrations: 1 µM (black trace), 10 µM (red trace), and 100 µM (grey trace). Traces represent means of n = 4 independent replicates for each condition. SD envelopes were not added for clarity reasons (B,C) Maximal hyperpolarizations induced by increasing concentrations of Dooku1. Histograms represent the maximal hyperpolarizations (V_Max) that were reached, from which were deduced the nominal resting membrane potential (E_m). In (B) values of the first hyperpolarization occurring immediately after Dooku1 injection; and in (C) values of the second hyperpolarization, when occurred, which was delayed in time. Histograms represent means ± SD of n = 4 experiments.