TABLE 1.
Type 8 capsular locus-encoded proteins: properties and similarities to proteins in the databases
| Type 8 gene | Location in nucleotide sequence | Predicted protein (no. of aa/no. of kDa) | GRAVYa score | Proposed function or product | Similar polypeptide(s) (no. of aa) | Database accession no. | Degree of identity (%)/degree of similarity (%) | Organism |
|---|---|---|---|---|---|---|---|---|
| cap8E | 5782–7149 | 455/52.0 | 0.159 | Undecaprenyl-phosphate glucose-1-phosphate transferase | Cap33fE (455) | O86888 | 96/97 | S. pneumoniae type 33F |
| Cps2E (455) | AAD10174 | 95/96 | S. pneumoniae type 2 | |||||
| Cps23fE (455) | AAC69528 | 94/95 | S. pneumoniae type 23F | |||||
| Cps19aE (453) | AAC78667 | 92/95 | S. pneumoniae type 19A | |||||
| cap8F | 7129–7633 | 165/19.5 | 0.002 | Unknown | Orf5 (161) | O30630 | 37/58 | E. coli |
| Cps14F (149) | P72514 | 35/56 | S. pneumoniae type 14 | |||||
| cap8G | 7634–8113 | 159/18.2 | −0.053 | β-GlcA transferase | Cps14G (167) | P72515 | 34/60 | S. pneumoniae type 14 |
| Orf6 (153) | O30631 | 33/52 | E. coli | |||||
| cap8H | 8126–9190 | 354/40.0 | −0.114 | Galactosyltransferase | Cap33fG (346) | O86890 | 27/51 | S. pneumoniae type 33F |
| PH1844 (381) | O59512 | 30/52 | Pyrococcus horikoshii | |||||
| cap8I | 9190–10650 | 486/55.3 | 0.818 | Oligosaccharide repeat unit transporter | Cps19bJ (481) | O07870 | 33/56 | S. pneumoniae type 19B |
| Cps14L (487) | O07342 | 26/43 | S. pneumoniae type 14 | |||||
| Cap33fL (471) | O86895 | 25/52 | S. pneumoniae type 33F | |||||
| cap8J | 10663–11391 | 242/28.4 | −0.381 | Unknown | C17G8.11C (356) | Q10323 | 35/49b | Schizosaccharomyces pombe |
| Cps14K (282) | O07341 | 32/50b | S. pneumoniae type 14 | |||||
| cap8K | 11375–12538 | 387/46.0 | 0.822 | Polysaccharide polymerase | Cps23fG (397) | AAC69530 | 21/41 | S. pneumoniae type 23F |
| cap8L | 12607–13845 | 412/46.5 | −0.250 | UDP-GlcDH | Cps2K (412) | AAD10180 | 96/98 | S. pneumoniae type 2 |
| Cap1K (410) | P96482 | 78/90 | S. pneumoniae type 1 | |||||
| Cap3A (394) | Q57346 | 57/74 | S. pneumoniae type 3 |
a
Grand average of hydropathy (26).
b
Sequence similarity is restricted to the N-terminal part of the protein (aa positions 1 to 100).