Extended Data Fig. 5. Associations between SV signatures, genetic variants and SNV signatures.

(A) The statistical significance (as determined by Wilcoxon Tests) of positive (enriched, shown in red) and negative (depleted, shown in blue) associations between each SV signature and of all recurrently altered somatic genetic alterations that are documented in the Cancer Gene Census⁴⁶. Shading within each box indicates level of significance as determined by the q value. (B) De-novo extracted SNV signatures (based on n=179 tumors). (C) Cosine similarity between de novo extracted SNV signatures and the COSMICv3 SBS-signatures. (D) SNV signature activity in every tumor. The hypermutant tumors on the left show signatures associated with hypermutation in COSMICv3. Signature 3, which is similar to the SBS3 homologous recombination deficiency signature, features prominently in many non-hypermutant tumors.