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. Author manuscript; available in PMC: 2023 Jul 24.
Published in final edited form as: Nat Cancer. 2022 Jul 4;3(8):994–1011. doi: 10.1038/s43018-022-00403-z

Figure 7. Association between the complex SV signatures and overall survival in midline gliomas.

Figure 7

(A) Associations between the fraction of SV signature activity attributed to complex SV signatures and overall survival for all midline gliomas (n= 103; rho = −0.32 and p=0.001, two-sided Spearman correlation test). (B) Cox proportional hazards analysis incorporating histone group, age, TP53 status and the combined complex SV signatures. Error bars show the 95% confidence interval of the hazard ratio. (C) Kaplan-Maier plot of a univariate analysis of the association between the complex SV signatures and overall survival, in which tumors were classified as Complex-SV if complex SV signatures contributed more than 20% of all SV signature activity. The number of patients in each group is indicated below the plot. The p-value represents a log-rank test. Error bands show the 95% confidence interval.