Table 2. Incidence rates of clinical outcomes.
| Total ( n = 780) | Provoked DVT ( n = 335) | Unprovoked DVT ( n = 445) | |||
|---|---|---|---|---|---|
| RVO absent ( n = 218) | RVO present ( n = 117) | RVO absent ( n = 201) | RVO present ( n = 244) | ||
| Recurrent VTE | |||||
| No. of events (%) | 109/619 (17.6) | 16/204 (7.8) | 9/92 (9.8) | 49/192 (25.5) | 35/131 (26.7) |
| Per 100 pt-y (95% CI) | 4.4 (3.6–5.3) | 1.9 (1.1–3.1) | 2.4 (1.1–4.4) | 6.7 (5.0–8.8) | 6.8 (4.8–9.3) |
| PTS | |||||
| No. of events (%) | 158 (20.3) | 24 (11.0) | 34 (29.1) a | 43 (17.6) | 57 (28.4) c |
| Per 100 pt-y (95% CI) | 11.7 (10.1–13.6) | 6.0 (3.9–8.9) | 17.5 (12.5–23.6) | 10.1 (7.4–13.3) | 17.3 (13.4–21.8) |
| Arterial event | |||||
| No. of events (%) | 53 (6.8) | 7 (3.2) | 10 (8.5) b | 15 (6.1) | 21 (10.4) |
| Per 100 pt-y (95% CI) | 1.6 (1.2–2.1) | 0.8 (0.3–1.6) | 2.1 (1.0–3.9) | 1.5 (0.8–2.4) | 2.5 (1.6–3.8) |
| Cancer | |||||
| No. of events (%) | 55 (7.1) | 10 (4.6) | 6 (5.1) | 17 (7.0) | 22 (10.9) |
| Per 100 pt-y (95% CI) | 1.7 (1.3–2.2) | 1.1 (0.9–2.8) | 1.2 (0.6–2.9) | 1.7 (1.5–3.5) | 2.6 (2.0–4.5) |
Abbreviations: CI, confidence interval; DVT, deep vein thrombosis; PTS, post-thrombotic syndrome; pt-y, patient-years; RVO, residual venous obstruction; VTE, venous thromboembolism.
Note: Outcomes are reported for patients with RVO assessment ( n = 780/825). Incidences of recurrent VTE are displayed for patients that stopped anticoagulant therapy ( n = 619/780), thus excluding “high recurrence risk” patients. PTS was assessed during 2-year follow-up.
a
p < 0.001 and b p = 0.034 vs provoked DVT with RVO absent; c p = 0.007 vs. unprovoked DVT with RVO absent.