Table 4. Associations of high D-dimer with clinical outcomes.

	Total	Provoked DVT	Unprovoked DVT
Recurrent VTE, HR (95% CI)	3.51 (2.24–5.48) a	4.56 (1.78–11.68) a	3.16 (1.91–5.24) a
PTS, HR (95% CI)	1.43 (0.93–2.20)	1.46 (0.76–2.79)	1.30 (0.72–2.34)
Arterial event, HR (95% CI)	1.04 (0.50–2.17)	1.01 (0.27–3.80)	0.94 (0.39–2.28)
Cancer, HR (95% CI)	0.67 (0.30–1.49)	0.32 (0.08–1.23) a	1.00 (0.42–2.37)

Abbreviations: CI, confidence interval; DVT, deep vein thrombosis; HR, hazard ratio; PTS, post-thrombotic syndrome; VTE, venous thromboembolism.

Footnote: D-dimer levels were considered high at ≥ 500 ng/mL. Each association was adjusted for duration of anticoagulant therapy, age, and residual venous obstruction. Additionally, recurrent VTE was adjusted for unprovoked DVT, previous VTE, venous insufficiency and hypertension; PTS was adjusted for body mass index, venous insufficiency, iliofemoral DVT and smoking; arterial events were adjusted for hypertension, antiplatelet drug use and smoking; cancer was adjusted for hypertension.

^ap -Value <0.05.