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. 2023 May 12;123(8):808–839. doi: 10.1055/a-2052-9175

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — Biotransformation and metabolization of the oral P2Y12-inhibitors. Antithrombotic therapy can be personalized by (1) using CYP2C19 genotype-guided therapy, which is the only genetic polymorphism for which a genotype-guided therapy is assessed in randomized clinical trials or (2) assessing the actual responsiveness to antiplatelet therapy by measuring on-treatment platelet reactivity, which is influenced by different modifiable and nonmodifiable factors.