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. 2023 May 12;123(8):808–839. doi: 10.1055/a-2052-9175

Table 2. Overview of reversal agents. The agents are categorized in reversal of dabigatran (anti-IIa), anti-Xa anticoagulants or with universal action. Furthermore, the agents were divided in proteins or small molecules and by mechanism of action (decoy or non-decoy). ( ): protein-based, decoy; ( ): protein-based, non-decoy; ( ): small molecule, decoy; ( ): small molecule, non-decoy.

Anti-IIa Anti-Xa Haemostasis enhancing Universal
Idarucizumab ( Inline graphic ) Andexanet alfa ( Inline graphic ) FVIIa ( Inline graphic ) Ciraparantag ( Inline graphic )
Gamma-thrombin-S195A ( Inline graphic ) GladomainlessFXa-alfa2M ( Inline graphic ) (a)PCC ( Inline graphic ) OKL-1111 ( Inline graphic )
FXa-I16L ( Inline graphic )
FX-C ( Inline graphic )
FX-Phe174 ( Inline graphic )
SuperVa ( Inline graphic )