Table 4. Factor XI(a) inhibition.
| Type of FXI inhibition | Administration | Frequency | Onset of action | Offset of action | Renal excretion | |
|---|---|---|---|---|---|---|
| ASOs | Block biosynthesis | Parenteral | Weekly to monthly | Slow (weeks) |
Slow (weeks) | No |
| Antibodies | Bind target protein | Parenteral | Monthly | Rapid (hours to days) |
Slow (weeks) | No |
| Small molecules | Bind target protein | Oral (or parenteral) | Daily | Rapid (minutes to hours) |
Fast | Yes |
| Natural inhibitors | Bind target protein | Parenteral | Daily | Rapid (minutes) | Fast | Uncertain |
| Aptamers | Bind target protein | Parenteral | Daily | Rapid (minutes to hours) |
Fast | No |