Table 3.

Multivariate Cox model of OS in pretransplant subgroups of patients who tested as MRD⁺ and MRD-negative

Pretransplant MRD status	Variable	Reference level	HR (95% CI)	P
MRD+	FLT3 status: present	Absent	1.32 (0.87-2.00)	.19
	Cytogenetic risk group: adverse	Favorable/intermediate risk	1.38 (0.91-2.09)	.13
	Posttransplant MRD status (time-dependent): positive	Negative	2.70 (1.76-4.15)	< .001
	Chronic GVHD (time-dependent): yes	No	0.92 (0.53-1.62)	.78
MRD-negative	FLT3 status: present	Absent	1.31 (0.88-1.97)	.18
	Cytogenetic risk group: adverse	Favorable/intermediate risk	1.61 (1.08-2.39)	.019
	Posttransplant MRD status (time-dependent): positive	Negative	2.68 (1.79-4.03)	< .001
	Chronic GVHD (time-dependent): Yes	No	0.92 (0.54-1.57)	.77

MRD status and chronic GVHD analyzed as time-dependent variables.