Table 4.
Second-order feature results from linear mixed models using mean values as input for each of the tested features. Abbrev., S1=Nikon, S2=Olympus, Huron=S3, S1-3=Nikon-Huron histogram match, S2-3=Olympus-Huron histogram match.
| Feature | Scanner | Mean difference | Std. error | df | P-value | 95% confidence interval |
||
|---|---|---|---|---|---|---|---|---|
| Lower bound | Upper bound | |||||||
| Lumen roundness | S3 | S1-3 | 13.50 | 8.39 | 899.25 | .11 | -2.97 | 29.96 |
| S1 | 13.31 | 8.22 | 898.25 | .11 | -2.83 | 29.45 | ||
| S2-3 | 13.38 | 8.26 | 898.93 | .11 | -2.83 | 29.59 | ||
| S2 | 13.25 | 8.22 | 898.25 | .11 | -2.89 | 29.39 | ||
| S1-3 | S3 | -13.50 | 8.39 | 899.25 | .11 | -29.96 | 2.97 | |
| S1 | -0.18 | 8.39 | 899.25 | .98 | -16.65 | 16.28 | ||
| S2-3 | -0.12 | 8.42 | 898.71 | .99 | -16.64 | 16.41 | ||
| S2 | -0.25 | 8.39 | 899.25 | .98 | -16.71 | 16.22 | ||
| S1 | S3 | -13.31 | 8.22 | 898.25 | .11 | -29.45 | 2.83 | |
| S1-3 | 0.18 | 8.39 | 899.25 | .98 | -16.28 | 16.65 | ||
| S2-3 | 0.06 | 8.26 | 898.93 | .99 | -16.14 | 16.27 | ||
| S2 | -0.06 | 8.22 | 898.25 | .99 | -16.20 | 16.08 | ||
| S2-3 | S3 | -13.38 | 8.26 | 898.93 | .11 | -29.59 | 2.83 | |
| S1-3 | 0.12 | 8.42 | 898.71 | .99 | -16.41 | 16.64 | ||
| S1 | -0.06 | 8.26 | 898.93 | .99 | -16.27 | 16.14 | ||
| S2 | -0.13 | 8.26 | 898.93 | .99 | -16.34 | 16.08 | ||
| S2 | S3 | -13.25 | 8.22 | 898.25 | .11 | -29.39 | 2.89 | |
| S1-3 | 0.25 | 8.39 | 899.25 | .98 | -16.22 | 16.71 | ||
| S1 | 0.06 | 8.22 | 898.25 | .99 | -16.08 | 16.20 | ||
| S2-3 | 0.13 | 8.26 | 898.93 | .99 | -16.08 | 16.34 | ||
| Lumen area | S3 | S1-3 | 0.00E+00 | 1.51E-04 | 914.19 | .24 | -1.19E-04 | 4.74E-04 |
| S1 | -1.00E-03 | 1.51E-04 | 914.19 | <.001 | -1.53E-03 | -9.41E-04 | ||
| S2-3 | 4.49E-05 | 1.51E-04 | 914.19 | .77 | -2.52E-04 | 3.41E-04 | ||
| S2 | 0.00E+00 | 1.51E-04 | 914.19 | .002 | -7.63E-04 | -1.70E-04 | ||
| S1-3 | S3 | 0.00E+00 | 1.51E-04 | 914.19 | .24 | -4.74E-04 | 1.19E-04 | |
| S1 | -1.00E-03 | 1.51E-04 | 914.19 | <.001 | -1.71E-03 | -1.12E-03 | ||
| S2-3 | 0.00E+00 | 1.51E-04 | 914.19 | .38 | -4.29E-04 | 1.64E-04 | ||
| S2 | -1.00E-03 | 1.51E-04 | 914.19 | <.001 | -9.41E-04 | -3.48E-04 | ||
| S1 | S3 | 1.00E-03 | 1.51E-04 | 914.19 | <.001 | 9.41E-04 | 1.53E-03 | |
| S1-3 | 1.00E-03 | 1.51E-04 | 914.19 | <.001 | 1.12E-03 | 1.71E-03 | ||
| S2-3 | 1.00E-03 | 1.51E-04 | 914.19 | <.001 | 9.86E-04 | 1.58E-03 | ||
| S2 | 1.00E-03 | 1.51E-04 | 914.19 | <.001 | 4.75E-04 | 1.07E-03 | ||
| S2-3 | S3 | -4.49E-05 | 1.51E-04 | 914.19 | .77 | -3.41E-04 | 2.52E-04 | |
| S1-3 | 0.00E+00 | 1.51E-04 | 914.19 | .38 | -1.64E-04 | 4.29E-04 | ||
| S1 | -1.00E-03 | 1.51E-04 | 914.19 | <.001 | -1.58E-03 | -9.86E-04 | ||
| S2 | -1.00E-03 | 1.51E-04 | 914.19 | <.001 | -8.08E-04 | -2.15E-04 | ||
| S2 | S3 | 0.00E+00 | 1.51E-04 | 914.19 | .002 | 1.70E-04 | 7.63E-04 | |
| S1-3 | 1.00E-03 | 1.51E-04 | 914.19 | <.001 | 3.48E-04 | 9.41E-04 | ||
| S1 | -1.00E-03 | 1.51E-04 | 914.19 | <.001 | -1.07E-03 | -4.75E-04 | ||
| S2-3 | 1.00E-03 | 1.51E-04 | 914.19 | <.001 | 2.15E-04 | 8.08E-04 | ||
| Epithelium roundness | S3 | S1-3 | 1.02 | 0.63 | 914.97 | .10 | -0.21 | 2.25 |
| S1 | 1.02 | 0.63 | 914.97 | .10 | -0.21 | 2.25 | ||
| S2-3 | 1.02 | 0.63 | 914.97 | .10 | -0.21 | 2.25 | ||
| S2 | 1.02 | 0.63 | 914.97 | .10 | -0.21 | 2.25 | ||
| S1-3 | S3 | -1.02 | 0.63 | 914.97 | .10 | -2.25 | 0.21 | |
| S1 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S2-3 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S2 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S1 | S3 | -1.02 | 0.63 | 914.97 | .10 | -2.25 | 0.21 | |
| S1-3 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S2-3 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S2 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S2-3 | S3 | -1.02 | 0.63 | 914.97 | .10 | -2.25 | 0.21 | |
| S1-3 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S1 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S2 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S2 | S3 | -1.02 | 0.63 | 914.97 | .10 | -2.25 | 0.21 | |
| S1-3 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S1 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| S2-3 | 0.00 | 0.63 | 914.97 | 1.00 | -1.23 | 1.23 | ||
| Epithelium thickness | S3 | S1-3 | 8.00E-03 | 4.62E-03 | 914.84 | .09 | -1.32E-03 | 1.68E-02 |
| S1 | 5.00E-03 | 4.62E-03 | 914.84 | .25 | -3.72E-03 | 1.44E-02 | ||
| S2-3 | 8.00E-03 | 4.62E-03 | 914.84 | .09 | -1.28E-03 | 1.69E-02 | ||
| S2 | 7.00E-03 | 4.62E-03 | 914.84 | .14 | -2.28E-03 | 1.59E-02 | ||
| S1-3 | S3 | -8.00E-03 | 4.62E-03 | 914.84 | .09 | -1.68E-02 | 1.32E-03 | |
| S1 | -2.00E-03 | 4.62E-03 | 914.84 | .60 | -1.15E-02 | 6.67E-03 | ||
| S2-3 | 3.34E-05 | 4.62E-03 | 914.84 | .99 | -9.03E-03 | 9.10E-03 | ||
| S2 | -1.00E-03 | 4.62E-03 | 914.84 | .84 | -1.00E-02 | 8.11E-03 | ||
| S1 | S3 | -5.00E-03 | 4.62E-03 | 914.84 | .25 | -1.44E-02 | 3.72E-03 | |
| S1-3 | 2.00E-03 | 4.62E-03 | 914.84 | .60 | -6.67E-03 | 1.15E-02 | ||
| S2-3 | 2.00E-03 | 4.62E-03 | 914.84 | .60 | -6.64E-03 | 1.15E-02 | ||
| S2 | 1.00E-03 | 4.62E-03 | 914.84 | .76 | -7.63E-03 | 1.05E-02 | ||
| S2-3 | S3 | -8.00E-03 | 4.62E-03 | 914.84 | .09 | -1.69E-02 | 1.28E-03 | |
| S1-3 | -3.34E-05 | 4.62E-03 | 914.84 | .99 | -9.10E-03 | 9.03E-03 | ||
| S1 | -2.00E-03 | 4.62E-03 | 914.84 | .60 | -1.15E-02 | 6.64E-03 | ||
| S2 | -1.00E-03 | 4.62E-03 | 914.84 | .83 | -1.01E-02 | 8.07E-03 | ||
| S2 | S3 | -7.00E-03 | 4.62E-03 | 914.84 | .14 | -1.59E-02 | 2.28E-03 | |
| S1-3 | 1.00E-03 | 4.62E-03 | 914.84 | .84 | -8.11E-03 | 1.00E-02 | ||
| S1 | -1.00E-03 | 4.62E-03 | 914.84 | .76 | -1.05E-02 | 7.63E-03 | ||
| S2-3 | 1.00E-03 | 4.62E-03 | 914.84 | .83 | -8.07E-03 | 1.01E-02 | ||
| Cell fraction | S3 | S1-3 | 0.14 | 0.11 | 914.40 | .19 | -0.07 | 0.36 |
| S1 | 0.14 | 0.11 | 914.40 | .2 | -0.07 | 0.35 | ||
| S2-3 | 0.15 | 0.11 | 914.40 | .17 | -0.06 | 0.36 | ||
| S2 | 0.15 | 0.11 | 914.40 | .17 | -0.06 | 0.36 | ||
| S1-3 | S3 | -0.14 | 0.11 | 914.40 | .19 | -0.36 | 0.07 | |
| S1 | 0.00 | 0.11 | 914.40 | .98 | -0.22 | 0.21 | ||
| S2-3 | 0.01 | 0.11 | 914.40 | .96 | -0.21 | 0.22 | ||
| S2 | 0.01 | 0.11 | 914.40 | .94 | -0.20 | 0.22 | ||
| S1 | S3 | -0.14 | 0.11 | 914.40 | .2 | -0.35 | 0.07 | |
| S1-3 | 0.00 | 0.11 | 914.40 | .98 | -0.21 | 0.22 | ||
| S2-3 | 0.01 | 0.11 | 914.40 | .94 | -0.20 | 0.22 | ||
| S2 | 0.01 | 0.11 | 914.40 | .93 | -0.20 | 0.22 | ||
| S2-3 | S3 | -0.15 | 0.11 | 914.40 | .17 | -0.36 | 0.06 | |
| S1-3 | -0.01 | 0.11 | 914.40 | .96 | -0.22 | 0.21 | ||
| S1 | -0.01 | 0.11 | 914.40 | .94 | -0.22 | 0.20 | ||
| S2 | 0.00 | 0.11 | 914.40 | .99 | -0.21 | 0.21 | ||
| S2 | S3 | -0.15 | 0.11 | 914.40 | .17 | -0.36 | 0.06 | |
| S1-3 | -0.01 | 0.11 | 914.40 | .94 | -0.22 | 0.20 | ||
| S1 | -0.01 | 0.11 | 914.40 | .93 | -0.22 | 0.20 | ||
| S2-3 | 0.00 | 0.11 | 914.40 | .99 | -0.21 | 0.21 | ||
| Epithelium area | S3 | S1-3 | 0.14 | 0.02 | 764.00 | <.001 | 0.09 | 0.19 |
| S1 | -0.04 | 0.02 | 764.00 | .11 | -0.09 | 0.01 | ||
| S2-3 | 0.14 | 0.02 | 764.00 | <.001 | 0.09 | 0.18 | ||
| S2 | -0.19 | 0.02 | 764.00 | <.001 | -0.23 | -0.14 | ||
| S1-3 | S3 | -0.14 | 0.02 | 764.00 | <.001 | -0.19 | -0.09 | |
| S1 | -0.18 | 0.02 | 764.00 | <.001 | -0.23 | -0.13 | ||
| S2-3 | -0.01 | 0.02 | 764.00 | .76 | -0.06 | 0.04 | ||
| S2 | -0.33 | 0.02 | 764.00 | <.001 | -0.38 | -0.28 | ||
| S1 | S3 | 0.04 | 0.02 | 764.00 | .11 | -0.01 | 0.09 | |
| S1-3 | 0.18 | 0.02 | 764.00 | <.001 | 0.13 | 0.23 | ||
| S2-3 | 0.17 | 0.02 | 764.00 | <.001 | 0.13 | 0.22 | ||
| S2 | -0.15 | 0.02 | 764.00 | <.001 | -0.20 | -0.10 | ||
| S2-3 | S3 | -0.14 | 0.02 | 764.00 | <.001 | -0.18 | -0.09 | |
| S1-3 | 0.01 | 0.02 | 764.00 | .76 | -0.04 | 0.06 | ||
| S1 | -0.17 | 0.02 | 764.00 | <.001 | -0.22 | -0.13 | ||
| S2 | -0.32 | 0.02 | 764.00 | <.001 | -0.37 | -0.27 | ||
| S2 | S3 | 0.19 | 0.02 | 764.00 | <.001 | 0.14 | 0.23 | |
| S1-3 | 0.33 | 0.02 | 764.00 | <.001 | 0.28 | 0.38 | ||
| S1 | 0.15 | 0.02 | 764.00 | <.001 | 0.10 | 0.20 | ||
| S2-3 | 0.32 | 0.02 | 764.00 | <.001 | 0.27 | 0.37 | ||