Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Working model for the role of PAF49 in rDNA transcription. PAF49 plays an important role in anchoring the heterodimer to the core polymerase. Without PAF49, the interaction between PAF53 and Pol I is destabilized causing PAF53 to disassociate from the polymerase. Pol I without the heterodimer is inactive. IA represents active polymerase.
