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. 2023 Jun 24;299(8):104951. doi: 10.1016/j.jbc.2023.104951

Figure 8.

Figure 8

Domains of yeast A34 and mammalian PAF49.A, cartoon depicting the modular domains of the yeast A34, human PAF49, and mouse PAF49 homologs. The domain names are labeled above with brackets. Light orange represents the dimerization domain, magenta represents the ordered arm that facilitates binding to the polymerase, and green represents the disordered arm of the PAF49 homologs. The domain boundaries of yA34 are adapted from (67). The demarcations for the domains of the mammalian PAF49 homologs are adapted from (30, 36, 61). B, the cryo-EM structures of yA34 (adapted from PDB 5w66) and hPAF49 (adapted from PDB 7OB9). The dimerization domain and the arm of the homologs are indicated. The amino acids (aa) represented in each structure are also shown.