表1.
新辅助治疗方案
| Neoadjuvant systemic therapy | Application plan of drugs |
|---|---|
| Platinum-doublet chemotherapya | Carboplatin AUC 5 or AUC 6 day 1, Paclitaxel 175 mg/m² or 200 mg/m² day 1 (any histology); Cisplatin 75 mg/m² day 1, Pemetrexed 500 mg/m² day 1 (non-squamous histology); Cisplatin 75 mg/m² day 1, Gemcitabine 1,000 mg/m² or 1,250 mg/m² days 1 and 8 (squamous histology); Cisplatin 75 mg/m² day 1, Paclitaxel 175 mg/m² or 200 mg/m² day 1 (any histology) |
| Chemotherapy regimens for patients Not candidates for cisplatin-based therapyb | Carboplatin AUC 5 or AUC 6 day 1, Pemetrexed 500 mg/m² day 1 (non-squamous histology); Carboplatin AUC 5 or AUC 6 day 1, Gemcitabine 1,000 mg/m² or 1,250 mg/m² days 1 and 8 (squamous histology) |
| Preferred (non-squamous) | Cisplatin 75 mg/m2 day 1, Pemetrexed 500 mg/m2 day 1, every 21 days for 4 cycles |
| Preferred (squamous) | Cisplatin 75 mg/m2 day 1, Gemcitabine 1,250 mg/m2 days 1 and 8, every 21 days for 4 cycles; Cisplatin 75 mg/m2 day 1, Docetaxel 75 mg/m2 day 1, every 21 days for 4 cycles |
| Other recommended | Cisplatin 50 mg/m2 days 1 and 8; Vinorelbine 25 mg/m2 days 1, 8, 15 and 22, every 28 days for 4 cycles; Cisplatin 100 mg/m2 day 1, Vinorelbine 30 mg/m2 days 1, 8, 15 and 22, every 28 days for 4 cycles; Cisplatin 75 mg/m2-80 mg/m2 day 1, Vinorelbine 25 mg/m2-30 mg/m2 days 1 and 8, every 21 days for 4 cycles; Cisplatin 100 mg/m2 day 1, Etoposide 100 mg/m2 days 1-3, every 28 days for 4 cycles |
| Chemotherapy regimens for patients Not candidates for cisplatin-based therapy | Carboplatin AUC 6 day 1, Paclitaxel 200 mg/m2 day 1, every 21 days for 4 cycles; Carboplatin AUC 5 day 1, Gemcitabine 1,000 mg/m2 days 1 and 8, every 21 days for 4 cycles (squamous histology); Carboplatin AUC 5 day 1, Pemetrexed 500 mg/m2 day 1, every 21 days for 4 cycles (non-squamous histology) |
a: Neoadjuvant systemic therapy in patients candidates for immune checkpoint inhibitors; Nivolumab 360 mg and platinum-doublet chemotherapy every 3 weeks for 3 cycles; b: Neoadjuvant systemic therapy for patients Not candidates for immune checkpoint inhibitors; All chemotherapy regimens listed can be used for sequential chemotherapy/radiotherapy. AUC: area under the curve.