表4.
腺癌抗肿瘤治疗患者发生静脉血栓栓塞的Cox回归分析
| Characteristics | Univariate Cox regression analysis | Multivariate Cox regression analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | P | 95%CI | HR | P | 95%CI | ||
| Gender | 1.02 | 0.95 | 0.50-2.07 | ||||
| Age (yr) | 1.01 | 0.74 | 0.97-1.05 | ||||
| BMI (kg/m2) | 1.02 | 0.69 | 0.92-1.14 | ||||
| Smoking history | 1.23 | 0.58 | 0.59-2.55 | ||||
| Alcohol abuse | 1.77 | 0.18 | 0.76-4.08 | ||||
| Clinical stage | 1.20 | 0.68 | 0.49-2.94 | ||||
| Hypertension | 1.75 | 0.12 | 0.87-3.55 | ||||
| Diabetes | 0.52 | 0.37 | 0.12-2.18 | ||||
| Cardiovascular diseases | 0.64 | 0.66 | 0.09-4.65 | ||||
| Cerebrovascular diseases | 0.37 | 0.32 | 0.05-2.69 | ||||
| Pulmonary diseases | 2.08 | 0.23 | 0.63-6.83 | ||||
| Hepatic disease | 2.18 | 0.29 | 0.52-9.16 | ||||
| Kidney disease | 0.00 | 1.00 | 0.00-Inf | ||||
| Thyroid diseases | 0.00 | 1.00 | 0.00-Inf | ||||
| aCCI | 0.95 | 0.73 | 0.71-1.27 | ||||
| VTE history | 298.67 | 0.00 | 15.65-495.53 | 302.18 | <0.05 | 21.65-495.53 | |
| Site | 0.63 | 0.20 | 0.31-1.28 | ||||
| Pulmonary metastasis | 0.89 | 0.79 | 0.36-2.15 | ||||
| Lymph node metastasis | 1.36 | 0.45 | 0.61-3.04 | ||||
| Distant metastasis | 1.39 | 0.38 | 0.67-2.89 | ||||
| Surgery | 0.60 | 0.22 | 0.27-1.34 | ||||
| Pulmonary infection | 1.17 | 0.83 | 0.28-4.91 | ||||
| Radiotherapy | 2.58 | 0.04 | 1.06-6.27 | 2.69 | <0.05 | 1.10-6.55 | |
| Targeted therapy | 1.79 | 0.03 | 1.38-2.62 | 1.86 | <0.05 | 1.50-2.73 | |
| Immune therapy | 1.74 | 0.16 | 0.80-3.77 | ||||
| Pemetrexed | 0.60 | 0.29 | 0.23-1.55 | ||||
| Paclitaxel | 1.01 | 0.98 | 0.47-2.18 | ||||
| Platinum | 1.19 | 0.78 | 0.36-3.9 | ||||
| Thrombelastogram | 0.00 | 1.00 | 0.00-Inf | ||||
| Platelet (×109/L) | 0.49 | 0.49 | 0.07-3.61 | ||||
| APTT (s) | 0.65 | 0.56 | 0.16-2.74 | ||||
| PT (s) | 0.00 | 1.00 | 0.00-Inf | ||||
| FIB (g/L) | 2.02 | 0.34 | 0.47-8.61 | ||||
| PT-INR | 0.00 | 1.00 | 0.00-Inf | ||||
| D-D (mg/L) | 1.39 | 0.35 | 0.69-2.79 | ||||
Inf: infimum.