Figure 5.
Early life micronutrient deficiency alters gut microbiome functional pathways and SCFA profile. (A) Functional pathway bar plot. (B) Glucose homeostasis, (C) Entner-Doudoroff, (D) monosaccharides utilization, (E) disaccharide utilization, (F) amino sugar utilization, (G) polysaccharide utilization, (H) Short-chain fatty acid analysis. (I) SCFA and fasting glucose correlation analysis. Gut microbiome functional pathway analysis, central metabolism (J), fatty acids (K), protein metabolism (L), branched-chain amino acid metabolism, isoleucine (M), leucine (N) and valine (O). All y axis values represent their percent abundance in the metagenomic functional dataset. Wilcoxon tests were used to calculate all p values, which were then FDR corrected. SCFA analysis represented as q values. Statistical values represented as *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, +p > 0.05, n/s, not significant. SCFA, short-chain fatty acid.
