Table 3.
Interaction between miRNAs and lead compounds.
| miRNA | Human/animal Study | Dose | Cell line | Dose | Targets | Observations | Ref |
|---|---|---|---|---|---|---|---|
| miR-106b-5p (Up) | – | – | HT-22, PC12 | 0–100 μM, 48 h | XIAP | miR-106b-5p via targeting XIAP could inhibit cell viability. | [81] |
| miR-126 (Down), miR-155 (Up) | Human (Mexican women) | – | – | – | – | The expression mentioned miRNAs changed in Mexican women exposed to Pb. | [82] |
| miR-137 (Up) | Female SD rats | 250 p.p.m. | PC12, primary hippocampal neurons | 5 μM, 24 h | H3K27me3, EZH2, Wnt9b | Pb could lead to memory impairment via the miR-137/EZH2 axis. | [83] |
| miR-143-5p (Down) | C57BL/6 mice | 10 mg/kg, 1 month | Renal interstitial fibroblasts | 0–2 μM, 24 h | CCL20, Smad2/3, AKT, TGF-β1 | Administration of miR-143-5p via sponging CCL20 could decrease renal fibrosis induced by Pb. | [84] |
| miR-146a (−) | C57BL/6 mice | 200 mg/L, 15 days | BMECs | – | IRAK1, IL-2/8, PTX3 | In the mammary gland, Pb could increase inflammation levels. | [85] |
| miR-148a (−) | Human | – | – | – | Exposure to Pb could make an association between the methylation of DNA and miR-148a. | [86] | |
| miR-155 (Up) | Asian Carp | 1–2 mg/L | – | – | ERK, p38, IL-6, TNF-α, IL-1β | In the carp's head kidney, miR-155 could induce inflammation in the MAPK-dependent pathway. | [87] |
| miR-155, miR-221, (Up) | Human (North-Western India) | – | – | – | – | Both mentioned miRNAs increased in workers exposed to Pb. | [88] |
| miR-378a-3p (Up) | male C57 mice | 250–1000 mg/L, 12 weeks | HT22 | 10–40 μM, for 24 h | SLC7A11, GPX4 | In a model of nerve injury induced by Pb, miR-378a-3p via sponging SLC7A11 could be involved in the induction of ferroptosis. | [89] |