Table 4.

Interaction between miRNAs and asbestos.

miRNA	Human/animal Study	Dose	Cell line	Dose	Targets	Observations	Ref
hsa-let-7a, miR-125a-5p, miR-320, miR-484, (Up)	Human (Malignant pleural mesothelioma patients)	–	–	–	WNT3, FGF9, TGFB2	The expression of miRNAs could be changed in pleural effusion induced by asbestos.	[90]
miR-30d (Down)	Human (pleural malignant mesothelioma patients)	–	NCI–H2452		Vimentin, CDH1, TWIST1	Exposure of NCI–H2452 cells to asbestos could suppress invasion or migration via miR-30d.	[91]
miR-30e-3p, miR-103a-3p, (Down)	Human (malignant pleural mesothelioma patients)	–	–	–	–	Extracellular vesicle miRNAs could be considered a biomarker of mentioned disease.	[92]
hsa-miR-98 (Down)	Human (Malignant pleural mesothelioma patients), GSE92636 database	–	–	–	–	Higher expression of miR-98 was associated with poor overall survival in patients with mesothelioma.	[93]
miR-126, miR-222, (Up)	Human (samples from malignant mesothelioma patients)	–	HUVECs, BEAS-2B, IMR-90, Met-5A	5 μg/cm2	EGFR, AKT, ERK, p38, PARP1	Exposed cells to asbestos via activating the EGFR pathway could increase the expression of mentioned miRs	[94]
miR-126 (Up), miR-520g (−), miR-222 (Up), miR-205 (−)	Human (non–small cell lung cancer patients)	–	–	–	–	Mentioned-miRNAs could be changed in lung malignancies caused by asbestos.	[20]
miR-197-3p (dysregulated)	Human	–	–	–		Serum levels of miR-197-3p could be dysregulated in workers exposed to asbestos.	[95]
miRNA profile, miR-197-3p, miR-1281, (Up)	Human (malignant pleural mesothelioma patients)	–	–	–	–	In workers who are ex-exposed to asbestos, the level of mentioned miRNAs increased.	[96]
miR-199/214 (Up)	specific pathogen-free F1 hybrid rats	–	MeT5A	–	Twist1, Akt, ERK, PTEN	In an animal model of sarcomatoid mesothelioma induced by asbestos, higher expression of miR-199/214 via targeting Twist1 could increase tumorigenesis.	[97]