Table 5.
Interaction between miRNAs and mercury.
| miRNA | Human/animal Study | Dose | Cell line | Dose | Targets | Observations | Ref |
|---|---|---|---|---|---|---|---|
| hsa-miR-92a, hsa-miR-486, (Up) | Human (workers exposed to mercury) | – | 293T, HUVECs | 0–10 μM, 24 h | NF-κB, KLF4, COX-2 | Both mentioned miRNAs via afecting NF-κB activity could lead to mercury toxicity. | [98] |
| miR-124-3p (−), miR-125-5p (Up), miR-127-3p (Up) | Human (amalgam filling patients and Dentists) | – | – | – | – | There is a relationship between serum mercury levels of miRNAs. | [99] |
| 9 upregulated (such as miR-141, miR-196b), 5 downregulated (such as miR-217, miR-296) | – | – | H9, hESCs | 0–500 nM | SOX2, FGF4, DNMT3B, COL2A1 | Methyl Mercury could Induce neuronal toxicity and change the expression of miRNAs. | [100] |