Table 7.
Interaction between miRNAs and a combination of hazardous compounds.
| Compounds | miRNA | Human/animal Study | Dose | Cell line | Dose | Targets | Observations | Ref |
|---|---|---|---|---|---|---|---|---|
| Inorganic arsenic (iAs), manganese (Mn), CdCl2 | miR-146a, (Up in iAS), (Down in CdCl2) | C57BL/6J WT mice | 0.1 mg As/L | INS-1832/13, | iAs (1 μM), CdCl2 (5 μM), Mn (25 μM), 24 h | NF-κB, Camk2a | In INS-1832/13 cells (i.e. insulinoma cells), arsenic had more powerful damaging effects compared to others. | [112] |
| Pb, As, and CdCl2 | miR-222 (Up) | – | – | Balb/c 3T3 | NaAsO2 (2 μM), Pb (5 μM), and CdCl2 (2 μM) | Rad51c | A mixture of all hazardous materials could lead to cellular transformation via the miR-222/Rad51c axis. | [113] |
| Pb and Mercury | miR-575, miR-4286, (Down) | Human (pregnant women) | – | – | – | – | In the human cervix of pregnant women exposed to mercury and Pb, the miRNA expression was altered. | [114] |
| CdCl2 and NaAsO2 | miR-let7a, miR-146a, (Down) | male Wistar rats | NaAsO2 (5 mg/kg), CdCl2 (1 mg/kg), one month | – | – | – | Arsenite and CdCl2 could lead to organ toxicity. | [115] |