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. 2023 Jul 6;5(7):1188–1203. doi: 10.1038/s42255-023-00834-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Number of significantly regulated genes with obesity in each LM cell subpopulation (Supplementary Table 9). b-e, Heatmap of gene expression (log₂ RPKM) of chemokines, chemokine-receptors, cytokines, M1 and M2 markers, and pattern recognition receptors in LM cell populations with obesity. Symbol indicates significantly regulated genes (adjusted P < 0.01). f, Body mass index (BMI) of lean individuals (n=7) and individuals with obesity (n=13) (lean vs IS P<0.0001, lean vs IR P<0.0001 and lean vs T2D P<0.0001). g, Haemoglobin A1c (HbA1c) levels in patients with obesity (n=13; IS vs T2D P= 0.0014 and IR vs T2D P=0.0024). h, Fasting glucose (IS vs T2D P=0.0057 and IR vs T2D P=0.0015) and i, insulin levels in patients with obesity (n=13). j, Triglyceride levels in the circulation of patients with obesity (n=13). k, Total cholesterol levels in patients with obesity (n=13). Data are presented as mean ± s.e.m. P values were calculated by one-way ANOVA with adjustment for multiple comparisons (f-k). **p < 0.01 and ****p < 0.0001. DEGs, differentially expressed genes; Reads per kilobase of exon model per million mapped reads, Reads Per Kilobases Million; IS, insulin sensitivity; IR, insulin resistance; T2D, type 2 diabetes; BMI, body mass index; ns, not significant.

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