Table 1.
Clinical characteristics of patients included in the study: cohort 1
| Clinical parameter | Lean (n = 12) | Obesity (n = 13) |
|---|---|---|
| Age, years (mean, range) | 62 (26–83) | 40 (28–56) |
| Sex, female/male (n) | 6/6 | 13/0 |
| BMI, kg m−2, (mean, range) | 23 (20–25) | 38 (35–41) |
| Diabetes (n) | NA | 3 |
| HSI (mean, range) | NA | 52 (44–60) |
| HbA1c, mmol mol−1 (mean, range) | NA | 39 (27–57) |
| HOMA-IR | NA | 6.1 (2.0–10.4) |
| Fasting insulin, mIU l−1 (mean, range) | NA | 23 (11–75) |
| Fasting glucose, mmol l−1 (mean, range) | NA | 6.2 (4.6–8.3) |
| Creatinine, µmol l−1 (mean, range) | NA | 65 (45–89) |
| ALT, µkat l−1 (mean, range) | NA | 0.6 (0.3–1.4) |
| AST, µkat l−1 (mean, range) | NA | 0.4 (0.2–0.8) |
| GGT, µkat l−1 (mean, range) | NA | 1.2 (0.2–3.5) |
| Total cholesterol, mmol l−1 (mean, range) | NA | 5.1 (3.7–6.4) |
| LDL cholesterol, mmol l−1 (mean, range) | NA | 3.1 (1.7–4.3) |
| HDL cholesterol, mmol l−1 (mean, range) | NA | 1.2 (1.0–1.5) |
| Triglycerides, mmol mol−1 (mean, range) | NA | 2.0 (0.7–3.4) |
HbA1c, hemoglobin A1c; IU, international units; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma glutamyl transferase; LDL, low-density lipoprotein; HDL, high-density lipoprotein; NA, not applicable.