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. 2023 Apr 3;7(7):943–958. doi: 10.1038/s41551-023-01017-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, 4D spatiotemporal secretion map for a hybridoma cell before and after division along with the corresponding optical images at selected time points that indicate secretion only for the daughter cells. The yellow lines around the cells define the boundary of the cells extracted by machine-learning algorithms. b, TIC curves that show type I cell behaviour for the daughter cells. c, Secretion area curves for the cells after mitosis. d, 4D spatiotemporal secretion map for a hybridoma cell before and after division with obvious secretion in both phases. e, TIC curves illustrating type II behaviour for the mother cell and type I behaviour for the daughter cells. f, Secretion area curves before and after mitosis. The grey boxes represent the time of mitosis and temporary changes in intensity due to cell movements before the cells settled down in their new positions.