Table 2.
Baseline comorbidities and history of surgical procedures in the AA and matched non-AA cohorts
| History of comorbid conditions, n (%) | AA cohort (n = 8784) | Non-AA cohort (n = 26,352) | AT/AU subtype (n = 599) | Non-AT/AU subtype (n = 8185) |
|---|---|---|---|---|
| Hypertension | 2233 (25.4) | 6409 (24.3) | 234 (39.1) | 1999 (24.4) |
| Diabetes mellitus | 802 (9.1) | 2791 (10.6) | 81 (13.5) | 721 (8.8) |
| Hyperlipidemia | 2364 (26.9) | 6301 (23.9) | 235 (39.2) | 2129 (26.0) |
| Smoking | ||||
| Current | 754 (8.6) | 2269 (8.6) | 62 (10.4) | 692 (8.5) |
| Previous | 38 (0.4) | 157 (0.6) | 4 (0.7) | 34 (0.4) |
| Never | 416 (4.7) | 932 (3.5) | 26 (4.3) | 390 (4.8) |
| Unknown | 27 (0.3) | 48 (0.2) | 1 (0.2) | 26 (0.3) |
| Substance abuse | 228 (2.6) | 601 (2.3) | 18 (3.0) | 210 (2.6) |
| Obesity | ||||
| Yes | 999 (11.4) | 2556 (9.7) | 103 (17.2) | 896 (10.9) |
| COPD | 275 (3.1) | 832 (3.2) | 51 (8.5) | 224 (2.7) |
| Any primary malignancya | 373 (4.2) | 919 (3.5) | 50 (8.3) | 323 (3.9) |
| BCC | 87 (1.0) | 238 (0.9) | 8 (1.3) | 79 (1.0) |
| SCC | 52 (0.6) | 119 (0.5) | 10 (1.7) | 42 (0.5) |
| Cervical carcinoma in situ | 6 (0.1) | 20 (0.1) | 0 | 6 (0.1) |
| Malignant melanoma | 16 (0.2) | 47 (0.2) | 1 (0.2) | 15 (0.2) |
| Lymphoma | 29 (0.3) | 50 (0.2) | 3 (0.5) | 26 (0.3) |
| Female breast cancer | 78 (0.9) | 191 (0.7) | 14 (2.3) | 64 (0.8) |
| Acute myocardial infarction | 42 (0.5) | 108 (0.4) | 8 (1.3) | 34 (0.4) |
| Unstable angina | 15 (0.2) | 61 (0.2) | 2 (0.3) | 13 (0.2) |
| Ischemic stroke | 17 (0.2) | 42 (0.2) | 1 (0.2) | 16 (0.2) |
| Hemorrhagic stroke | 2 (< 0.1) | 6 (< 0.1) | 1 (0.2) | 1 (0) |
| Hospitalization due to heart failure | 64 (0.7) | 172 (0.7) | 9 (1.5) | 55 (0.7) |
| Coronary revascularization by PCI or CABG | 22 (0.3) | 76 (0.3) | 2 (0.3) | 20 (0.2) |
| DVT | 60 (0.7) | 133 (0.5) | 10 (1.7) | 50 (0.6) |
| PE | 28 (0.3) | 83 (0.3) | 4 (0.7) | 24 (0.3) |
| DVT or PE | 76 (0.9) | 188 (0.7) | 12 (2.0) | 64 (0.8) |
| ATE | 7 (0.1) | 27 (0.1) | 0 | 7 (0.1) |
| DVT or PE or ATE | 81 (0.9) | 208 (0.8) | 12 (2.0) | 69 (0.8) |
| History of any surgery in the last 6 months prior to index date | 117 (1.3) | 353 (1.3) | 17 (2.8) | 100 (1.2) |
AA alopecia areata, AT alopecia totalis, ATE arterial thromboembolism, AU alopecia universalis, BCC basal cell carcinoma, CABG coronary artery bypass graft, COPD chronic obstructive pulmonary disease, DVT deep vein thrombosis, PCI percutaneous coronary intervention, PE pulmonary embolism, SCC squamous cell carcinoma
aExcluding nonmelanoma skin cancer