There are numerous risk factors for venous thromboembolism, including systemic inflammation. Markers of venous thromboembolism risk include soluble fibrin monomer complex, thrombin–antithrombin complex, and prothrombin fragment 1 + 2.

Numerous studies have indicated that alopecia areata is associated with chronic systemic inflammation, with an increased level of proinflammatory cytokines.

In the present study, an increased level of soluble fibrin monomer complex and prothrombin fragment 1 + 2 in patients with alopecia areata compared with the control group was observed.

Alopecia areata may be associated with an increased risk of venous thromboembolism. Regular screening and preventive management of venous thromboembolism may be beneficial in patients with alopecia areata.