Table 1.
Summary of Franz diffusion data by time after first application
Time after first application (h) | CAL/BDP PAD emulsion cream (ng/cm2) | CAL/BDP topical suspension gel (ng/cm2) | p valuea |
---|---|---|---|
16 | 375 ± 86 | 175 ± 41 | 0.0361 |
24 | 665 ± 118 | 347 ± 90 | 0.0303 |
40 | 1437 ± 168 | 884 ± 196 | 0.0292 |
48 | 2049 ± 230 | 1223 ± 282 | 0.0238 |
64 | 3729 ± 372 | 2033 ± 356 | 0.0041 |
72 | 4909 ± 458 | 2117 ± 264 | 0.0004 |
Data are presented as the mean amount of BDP diffused through human epidermis ± standard error of the mean (SEM) (n = 6)
CAL/BDP Calcipotriene and betamethasone dipropionate, PAD polyaphron dispersion
p values were calculated using a Student’s t test at 95% confidence level