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. 2022 Dec 14;37(11):2176–2182. doi: 10.1038/s41433-022-02320-y

Table 1.

Overview of individual study attributes.

Article Country Journal Year Study Type Intervention Used Participants Fundoscopic Exclusion Rate of Macular Pathology Detection Type of Pathology detected
Sudhalkar et al. [8] India AJO 2019 Case series SD-OCT 1444 eyes of 1444 patients

- Fundoscopy done

- Eyes appearing abnormal on fundoscopic exam were excluded

SD-OCT:

133 eyes (9.21%)

SD-OCT:

Interface abnormalities = 94

Macular degeneration = 26

Foveal attenuation = 8

Macular oedema = 5

Miscellaneous = 3

Tognetto et al. [17] Italy Scientific Reports 2019 Cross-sectional study SD-OCT & SS-OCT (Biometer) 1089 eyes of 732 patients - Fundoscopy not done

SD-OCT

449 eyes (41.2%)

SS-OCT

364 eyes (33.4%)

SD-OCT

Full-thickness macular holes = 16 (1.5%),

Interface abnormalities = 33 (3%)

Macular degeneration = 210 (19.4%)

Macular oedema = 169 (15.6%)

Pinto et al. [15] Brazil JCRS 2019 Case series SD-OCT 952 eyes of 614 patients

- Fundoscopy done

- Eyes appearing abnormal on fundoscopic exam were excluded

SD-OCT:

47 eyes (4.9%)

SD-OCT

Interface abnormalities = 35 (3.7%)

Macular degeneration = 7 (0.4%)

Macular oedema = 4 (0.4%)

FTMH = 1 (0.1%)

Abdelmassih et al. [14] France JCRS 2018 Case series SD-OCT 401 eyes of 245 patients

- Fundoscopy done

- Eyes with abnormal fundoscopy findings were included in OCT intervention group

SD-OCT:

107 (26.7%)

Fundoscopy:

37 (9.23%)

SD-OCT

Macular degeneration = 66 (61.7%)

Interface abnormalities = 32 (30%)

Miscellaneous = 5 (4.6%)

Macular oedema = 4 (3.7%)

Kowallic et al. [11] Germany PLoS One 2018 Case series SD-OCT 162 eyes of 123 patients

- Fundoscopy done

- Eyes appearing abnormal on fundoscopic exam were excluded

SD-OCT:

20 eyes (12.35%)

Interface abnormalities = 10 (6.17%)

Macular degeneration = 6 (3.71%)

Miscellaneous = 4 (2.47%)

Huang et al. [9] China Scientific Reports 2018 Case series SD-OCT 992 eyes of 992 patients

- Fundoscopy done

- Eyes appearing abnormal on fundoscopic exam were excluded

SD-OCT:

294 eyes (25%)

SD-OCT:

Interface abnormalities = 135

Macular degeneration = 160

Miscellaneous = 46

Macular oedema = 22

FTMH  = 14

Zafar et al. [16] Pakistan JCRS 2017 Case series SS-OCT 155 eyes of 155 patients

- Fundoscopy done

- Eyes appearing abnormal on fundoscopic exam were excluded

SS-OCT:

17 eyes (10.9%)

SS-OCT:

Macular degeneration = 5

Interface abnormality = 6

Macular oedema = 2

Hirnschall et al. [10] Austria JCRS 2016 Case series SD-OCT & SS-OCT (Biometer) 125 eyes of 125 patients - Fundoscopy not done

SD-OCT:

65 eyes (54.2%)

SS-OCT:

38 eyes (28%)

SD-OCT:

Interface abnormalities = 30 (25%)

FTMH = 5 (4.2%)

Macular degeneration = 16 (13.4%)

Macular oedema = 16 (13.3%)

Klein et al. [13] USA JCRS 2016 Case series SD-OCT 265 eyes of 149 patients

- Fundoscopy done

- Eyes appearing abnormal on fundoscopic exam were excluded

SD-OCT:

35 eyes (13.2%)

SD-OCT:

Macular degeneration = 20 (7.55%)

Interface abnormalities = 11 (4.15%)

Macular oedema = 3 (1.13%)

Neto et al. [12] Germany Arq Bras Oftalmol 2015 Case series SD-OCT 98 eyes of 98 patients

- Fundoscopy done

- Eyes with abnormal fundoscopy findings were included in OCT intervention group

SD-OCT:

21 eyes (21.4%)

Fundoscopy:

11 eyes (11.2%)

Fundoscopy:

Macular degeneration = 11

SD-OCT:

Macular degeneration = 7

Interface abnormalities = 3

Creese et al. [5] Austria Clinical and Experimental Ophthalmology 2011 Case series SD-OCT 218 eyes of 149 patients

- Fundoscopy done

- Eyes appearing abnormal on fundoscopic exam were excluded

SD-OCT:

10 eyes (4.6%)

SD-OCT

Interface abnormalities = 5

Macular degeneration = 3

FTMH = 1

Macular oedema = 1