Figure 1.
Thiopurine-induced damage of bone marrow cells by Nudt15 R138C. Bone marrow of Nudt15+/+ mice and Nudt15R138C/R138C mice was analyzed at 0, 24, 48, and 72 h after peritoneal administration of 5 mg/kg 6-MP. Data are presented as the mean ± SD (N = 5 each condition). The experiment with one or two mice in each condition was performed independently four times. *p < 0.05, **p < 0.01, and ***p < 0.001. HSC, hematopoietic stem cell; MPP, multipotent progenitor; CMP, common myeloid progenitor; GMP, granulocyte–macrophage progenitor; MEP, megakaryocyte-erythroid progenitor.
