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. 2023 Jul 25;9:77. doi: 10.1038/s41421-023-00578-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a UMAP plot of four intestinal stem cell clusters. b Dot plot of the top four marker genes of the intestinal stem cell clusters. c Percentages of intestinal stem cell clusters. Means ± SD, two-way ANOVA. d UMAP plot colored by cell cycle phase based on the results of Scran analysis. e Percentages of intestinal stem cell cycles. Means ± SD, two-way ANOVA. f Venn diagram of ALF_DEGs drawn for each intestinal stem cell cluster. g GO term enrichment analysis for ALF_DEGs of each intestinal stem cell cluster. h Expression of genes related to mitosis in S2 between the control and model mice. i Top five terms in the GO term enrichment analysis for the ALF_DEGs in intestinal stem cells. j UMAP plot of specific IECs. k Violin plots showing key cell markers used to describe goblet cells, EECs, Paneth cells and tuft cells and link them to cell type. l Dot plot of the top two marker genes of specific IECs clusters. m Percentages of specific IECs clusters. Means ± SD, two-way ANOVA. n, o Volcano plot and top five terms in the GO term enrichment analysis for ALF_DEGs in goblet cells. p, q Clustered heatmap of the average expression of the top 100 ALF_DEGs in specific IECs/goblet cells. r Heatmap drawn for TFs specifically activated in specific IECs clusters. Number of mice: model group (n = 3), control group (n = 3).