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. 2023 Jul 25;9:77. doi: 10.1038/s41421-023-00578-4

Fig. 5. Ep300 inhibition attenuates intestinal and hepatic injury in D/L-induced ALF mice.

Fig. 5

a Analysis of the protein–protein interaction network for specific activation of TFs in Ent5 via STRING-Cytoscape. b Analysis of protein–protein interaction networks in Gob1 that specifically activate TFs via STRING-Cytoscape. c Schematic diagram of the mechanism of Ep300 regulation of intestinal cells. d Animal experimental design. e Representative images of the mice livers in each experimental group. f Activity of AST and ALT in mouse serum in the presence or absence of ABX, D/L and Ep300i (means ± SD, two-way ANOVA, ns, no significant difference. *P < 0.05. **P < 0.01. ***P < 0.001. ****P < 0.0001, n = 6–8 mice per group, same as below). g Representative pictures of H&E staining of the mouse liver. Scale bars, 50 μm. h Levels of iFABP and LPS in mouse serum in the presence or absence of ABX, D/L and Ep300i. i Representative pictures of H&E staining of the mouse intestine. Scale bars, 50 μm. j Representative pictures of TUNEL staining of the mouse liver and intestine in the presence or absence of D/L and Ep300i. Scale bars, 100 μm. k Correlation analysis of serum ALT, iFABP and LPS in mice.