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. 2023 Jul 25;9:77. doi: 10.1038/s41421-023-00578-4

Fig. 6. Ep300 inhibition attenuates ALF in mice by inhibiting specific cell cluster changes via the P38-JNK pathway.

Fig. 6

a, b Representative IF images of Apoa1, Saa1, Muc2 and Ido1 in the mouse ileum. Scale bars, 20 μm. c q-PCR analysis of mRNA levels in mouse intestinal (means ± SD, two-way ANOVA. *P < 0.05. **P < 0.01. ***P < 0.001. ****P < 0.0001, n = 5–7 mice, same as below). d Representative immunohistochemistry (IHC) images of ZO-1 in the mouse intestine. Scale bars, 100 μm. e q-PCR analysis of ZO-1 and Occludin mRNA levels in mouse intestinal. f P38, p-P38, JNK and p-JNK expression in mouse liver and intestinal, as analyzed by western blotting assay. g q-PCR analysis of mRNA levels in mouse liver.