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. 2023 Jul 25;9:77. doi: 10.1038/s41421-023-00578-4

Fig. 7. Ep300 inhibition regulates intestinal microorganism homeostasis.

Fig. 7

a Box plot showing the differences in Simpson and Shannon indices between groups (Wilcoxon rank sum test. *P < 0.05). b 3D PCoA plot based on the relative abundance of amplicon sequence variants (ASVs) showing bacterial structural clustering. c Heatmap of the relative abundance of species differing at the genus level (Kruskal–Wallis test). d Correlation analysis of serum biomarkers and differentially distributed species between groups of mice (Kruskal–Wallis test, *P < 0.05. **P < 0.01). e LEfSe showing the differences in abundance between groups. f Box plot of differences in KEGG pathways between groups predicted by PICRUSt2 (Kruskal–Wallis, *P < 0.05).