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. 2023 Jul 24;6:772. doi: 10.1038/s42003-023-05081-w

Fig. 3. Virological features of Omicron subvariants in vivo.

Fig. 3

Syrian hamsters were intranasally inoculated with B.1.1 (n = 4), BA.1 (n = 4), BA.2 (n = 4), and BA.5 (n = 4). A Viral RNA quantification and titration. Viral RNA load (left, middle) in the lung hilum and periphery and viral titer (right) in the lung periphery were quantified. B IHC of the SARS-CoV-2 N protein in the lungs of infected hamsters. Representative IHC panels of the viral N proteins in the lower lobe of lungs of the infected hamsters. The raw data at 2 d.p.i. are shown in Supplementary Fig. 5A. Scale bars, 500 µm. In A, viral RNA copies and titers at each day were compared using Tukey’s multiplicity correction. As for viral RNA copies in the lung hilum area, BA.5 had significant higher copies than BA.1 at 2 d.p.i. Of viral RNA copies in the lung periphery area, BA.5 had significant higher copies than BA.1 at 2 d.p.i. B.1.1 had significantly higher copies than BA1, BA2, and BA.5 at 5 d.p.i. As for viral titers in the lung periphery area, B.1.1 had significantly higher titers than BA1, BA2, and BA.5 at 2 d.p.i. B.1.1 had significantly higher titers than BA.1 and BA.2, and BA.5 at 5 d.p.i.