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. 2023 Jul 24;6:772. doi: 10.1038/s42003-023-05081-w

Fig. 4. Pathological features of Omicron subvariants.

Fig. 4

Syrian hamsters were intranasally inoculated with B.1.1 (n = 4), BA.1 (n = 4), BA.2 (n = 4), and BA.5 (n = 4). A Histopathological scoring of lung lesions. B H&E staining of the lungs of infected hamsters. Uninfected lung alveolar space and bronchioles are also shown. Scale bars, 200 μm. C Summary of the percentage of the section represented by the inflammatory area with type II pneumocytes at 5 d.p.i. The raw data are shown in Supplementary Fig. 6A. In C, data are the mean ± s.e.m. and each dot indicates the result from an individual hamster. In A, the total score at each day was compared using Tukey’s multiplicity correction. At 2 d.p.i, B.1.1 had significantly higher score than BA1, BA2, and BA.5. At 5 d.p.i., B.1.1 had significantly higher score than BA.1 and BA.2, and BA.5 had significantly higher score than BA.1. In C, the statistical significance of differences (*P < 0.05) was determined by the analysis of variance using Tukey’s multiplicity correction.