Figure 3.

Integrated heatmap with dot plot for performance comparisons in settings 1 and 2. The R² value is depicted as a size of the circle. Red and blue colors indicate RMSE values. The model with higher R² and lower RMSE value is considered to have good performance. Note that R² with a 0.0 value indicates that the R² values of each model exhibit negative values or zero. (a) In setting 1, the ridge model for panobinostat shows the best performance among other models (b) In setting 2, no model outperformed the ridge model for panobinostat in setting 1. R² R-squared value, RMSE root mean squared error.