Fig. 1. Quantitative autofluorescence (qAF) of Geographic Atrophy (GA) with soft drusen precursors.

A Color fundus photograph, shows generalized retinal pigment epithelial (RPE) thinning, scattered drusen peripherally. B Autofluorescence (AF) image. Three “dark” hypoautofluorescent (hypoAF) lesions suggest GA. C Quantitative fundus AF (qAF) image. One hypoAF lesion outlined in yellow was chosen as region-of interest (ROI), mean qAF, 26.46 qAF units; GA area, 0.73 mm². qAF is coded to the color bar in qAF units. D NIR image. GA lesions are hyperreflectant. Green line shows horizontal axis and extent of the SD-OCT scan. E SD-OCT scan. There is complete RPE and outer retinal atrophy (cRORA), with choroidal hypertransmission, absence of the RPE band and thinning of the overlying retina (bounded by yellow arrowheads). Soft drusen appear as hyperreflective mounds between the RPE and Bruch’s membrane (BrM) (red arrows). Blue box demarcates inset, F Magnified inset. cRORA is better visualized. BrM is visible as a thin hyperrflective band, with remaining RPE on either side. There is no evidence of basal laminar deposit in the form of RPE plateaus and/or split RPE/BrM complex.