Fig. 2. Quantitative autofluorescence (qAF) of Geographic Atrophy (GA) with subretinal drusenoid deposit (SDD) precursors and basal laminar deposit (BLamD).

A Color fundus photograph (CFP) shows GA adjacent to peripapillary atrophy. B Autofluorescence (AF) image shows “gray” hypoAF lesion with lobed edges corresponding to the GA in the CFP. HypoAF dots corresponding to SDD are confluent in the macula. C Quantitative fundus autofluorescence (qAF) image. Region-of interest (ROI), outlined in yellow; mean qAF, 46.81 qAF units; GA area, 5.86 mm². Peripapillary atrophy was not included. qAF is coded to the color bar in qAF units. D NIR image. The horizontal axis and extent of the SD-OCT scan through the ROI is indicated by the green line. E SD-OCT scan illustrates the features of incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA), with alternating segments of preserved and degenerated photoreceptors, and one <50 micrometer segment of partially preserved RPE (red arrowhead) The extent of GA is delineated by yellow arrowheads. SDDs are visualized as hyperreflective material between RPE and ellipsoid zone (red arrows). Blue box demarcates inset (F) Magnified inset showing BLamD. Bruch’s membrane is visible as a thin hyperreflective band. BLamD appears as a split RPE-BrM complex or “double-layer sign” at the right-hand red arrows and continuing temporally for ~1500 micrometers. The thick hyperreflective band is combined RPE and BlamD. There is a thin, speckled hyporeflective band separating it from BrM. Continuing along the left-hand red arrows, the RPE thins out with only BLamD remaining.