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. 2023 Jul 24;13:11951. doi: 10.1038/s41598-023-38760-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Virtual scenario of different pharmacodynamic efficiency and olaparib duration. Computed SUV*_max progressing with time for a real and a fictious case, having a different nominal personalized olaparib efficiency ε_PD and a different NAT duration. The progress is reported limited to Phase II of challenged proliferation. Case A: results from patient n.13 of our cohort; Case B: virtual case of patient n.13 with 20% decrement of ε_PD and a total NAT duration of 27 days instead of 21; t, time; d, days.