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. 2023 Jul 24;13:11922. doi: 10.1038/s41598-023-39093-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A treatment with pro-GA, a GGCT inhibitor, down-regulates the expression of c-Met and pRB in a mouse xenograft tumor model. Mice were treated with pro-GA or DMSO twice a week for 5 weeks. (a) Tumor sections were analyzed by immunohistochemistry with antibodies against c-Met (blue: nuclear; brown: c-Met). Magnification 400-fold. Scale bar 50 μm. (b) Tumor sections were analyzed by immunohistochemistry with antibodies against pRB Ser807/811 (brown). Magnification 200-fold. Scale bar 100 μm. (c) The number of pRB-positive cells in (b). A two-tailed Student’s t-test was used (N = 3 per group, **p < 0.01). The error bars represent the S. D.