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. 2023 Jul 24;13:11922. doi: 10.1038/s41598-023-39093-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A proposed graphical summary of the signaling cascades involved in down-regulation of c-Met upon the knockdown of GGCT in PC3 cells. (a) In many tumor cells, highly expressed GGCT inactivates RB via c-Met and proposed signaling cascades. (b) Depletion or inhibition of GGCT results in down-regulation of c-Met via the AMPK-STAT3 pathway, followed by RB activation.