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. 2023 Jul 25;14(7):462. doi: 10.1038/s41419-023-05992-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Pseudotime trajectories of malignant epithelial cells in patient P2 are colored by the pseudotime (a) and states (b). c Pseudotime trajectories splitted by epithelial cell subtypes in patient P2. d Box plot of differences in pseudotimes between AT2 and CLDN2⁺ AT2 cells. Wilcox test, unpaired. e Heatmap of the pseudotime-dependent expression alterations of epithelial subtype marker genes. f Pathway enrichment results based on the marker genes of each epithelial subtype. Colors represent different subtypes. P: hypergeometric distribution. g Violin plot of the expressions of CLDN2-relevant cellular senescence marker genes in different epithelial cell subtypes. h Violin plot of the differential expression of CLDN2-relevant cellular senescence marker genes between CLDN2⁺ AT2 cells from the tumor and normal tissues. Wilcox test, unpaired. ****P < 0.0001.