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. 2023 Jul 25;14(7):462. doi: 10.1038/s41419-023-05992-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Heatmap of the cell–cell interactions between different cell types. The row and column, respectively, stand for the source and target cell types of the interactions. The top and right colored bar plot respectively represent the sum of column and row of values displayed in the heatmap. b Scatter plot of the interaction strength of different cell types. c Bubble plot of the interactions originated from the CLDN2⁺ AT2 cells and mediated by MDK. d Bar plot of the summarized communication probabilities on signaling pathways based on the interactions from fibroblast cells to CLDN2⁺ AT2 cells. e UMAP plot of the subpopulations of fibroblast cells. Myo: myofibroblast, SMC: smooth muscle cells. f Bar plot of the average proportions of each fibroblast cell sub-population in tumor and tumor-adjacent tissues. Data represent mean ± s.d. *P < 0.05, t test, unpaired.