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. 2023 Jul 24;13:11932. doi: 10.1038/s41598-023-39141-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Characteristics of CCN. (a) The concept of our chitosan-collagen hydrogel nerve conduit (CCN). In this study, the inner lumen is 2.0 mm in diameter, and the thickness of the chitosan and collagen layers are 0.5 mm and 0.25 mm, respectively. Schwann cells are encapsulated in the inner layer at 1.0 × 10⁴ cells/tube. (b) An image of the CCN before transplantation. (c) An image of the CCN after transplantation to a sciatic nerve.