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. 2023 Jul 24;13:11932. doi: 10.1038/s41598-023-39141-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Enhanced nerve regeneration by CCN with SCs. (a) Representative images of regenerated sciatic nerves 12 weeks after transplantation. The transplanted CCN in the CCN+ and CCN− groups remains, despite the occurrence of bio-absorption. (b) Toluidine blue staining in the central axial sections reveals regenerated nerve fiber in all groups. (c) Quantitative analysis of the axonal area of the regenerated nerve fibers (axonal area = cross-sectional area × axon density). The CCN+ group has higher axonal area value than the CCN− and silicone+ groups, but the difference among the three groups is not significant.