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. 2023 Jul 24;13:11932. doi: 10.1038/s41598-023-39141-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Promoted axonal regrowth and remyelination by CCN with SCs. (a) Representative images of immunohistochemistry staining for anti-P0 and anti-NFH antibody, counterstained with Hoechst, at 12 weeks after transplantation. (b) Number of regenerated axons, (c) P0-positive area, (d) NFH-positive area. *P < 0.05. Quantitative analysis of the axial section immunofluorescence. The number of regenerated axons and P0-positive area in the CCN+ group is significantly larger than those in the CCN− and silicone+ groups, but there is no significant difference between the CCN− and silicone+ groups. These results indicate that SC-encapsulated CCN promotes axonal regrowth and remyelination of regenerated axons.