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. 2023 Jul 24;14:4456. doi: 10.1038/s41467-023-40081-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic flow chart to show the strategy. b H&E staining in TAA mice (TAA group) and Mito-Q-treated TAA mice (Mito-Q group) (Bar = 100 μm on the top and Bar = 30 μm on the bottom). c, d The serum levels of ALT and AST (n = 6 per group). e, f Ammonia levels in blood and brain (n = 6 per group). g, h Elisa results of antioxidative biomarkers of SOD and GPx in the blood (n = 7, 6 per group). i Schematic traces and analysis of the run time and average speed of the CatWalk test (n = 7). j Behavioral results of rotarod test (n = 7 per group). k Schematic traces and analysis of the total distance and average speed of open field test (n = 8, 9 per group). l ROS staining in the SNr of GAD2-Mito mice and quantitative analysis of ROS staining within SNr (n = 4 per group, Bar = 100 μm or 30 μm). m Western blot results and analysis of UCP2, SOD1, and GPX1 expression in SNr. n Western blot results and analysis of LC3B and PINK1 expression in SNr. o Western blot results and analysis of DRP1, p-DRP1(Ser616), MFN2, MFF, and FIS1 expression in SNr. Data are presented as means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 vs TAA. n = 3 per group in western blotting. Two-tailed, unpaired, Student’s t-test for all data except one-way ANOVA with LSD’s multiple comparison tests for l. Source data are provided as a Source Data file.