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. 2023 Jul 24;14:4456. doi: 10.1038/s41467-023-40081-8

Fig. 8. Mito-Q and Ucp2OE improved mitochondrial respiration in SNr of HE mice.

Fig. 8

ad Analysis of VO2 (a), VCO2 (b), RER (c), and Y-total activity (d) during the dark, during the light, and total test period in Sham, TAA + Saline, and TAA + Mito-Q groups (n = 5 per group). e Mito-Q alleviated TAA-induced hypothermia (n = 6 per group). f, g The temporal changes of mitochondrial State III (f) and State IV (g) respiration in SNr in different groups (n = 4 per group). h, i MitoXpress of average State III (h) and State IV (i) respiration in SNr in different groups (n = 4 per group). j Mitochondrial respiratory control rate (RCR) in SNr in different groups (n = 4 per group). k, l Activity of mitochondrial respiratory chain complex III (k) and IV (l) in SNr in different groups (n = 5 per group). m ATP levels in SNr in different groups. Data were presented as means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 vs with Sham or TAA + Saline. One-way ANOVA with LSD’s multiple comparison tests for all data. VO2 oxygen consumption, VCO2 carbon dioxide production, RER respiratory exchange ratio, RCR respiratory control rate. Source data are provided as a Source Data file.