Table 1.
Demographic, clinical and pathological characteristics of CM patients.
| Characteristics | Total (N = 79) | Orbital Exenteration (N = 32) | Eye-sparing (N = 47) | OR (95%Cl) | P |
|---|---|---|---|---|---|
| Age at diagnosis | |||||
| Median (range) | 55 (27–82) | 57 (35-82) | 53 (27–79) | 1.03 (0.99–1.07) | 0.12 |
| ≤60 years | 50 (63.3) | 18 (56.3) | 32 (68.1) | ref | |
| >60 years | 29 (36.7) | 14 (43.8) | 15 (31.9) | 1.66 (0.66–4.20) | 0.29 |
| Gender | |||||
| Female | 26 (32.9) | 8 (25.0) | 18(38.3) | ref | |
| Male | 53 (67.1) | 24 (75.0) | 29 (61.7) | 1.86 (0.69–5.03) | 0.22 |
| Laterality | |||||
| Left | 40 (50.6) | 13 (40.6) | 27 (57.4) | ref | |
| Right | 39 (49.4) | 19 (59.4) | 20 (42.6) | 1.97 (0.79–4.91) | 0.14 |
| Lesion involvement | |||||
| Caruncle | 20 (25.3) | 10 (31.3) | 10 (21.3) | 1.68 (0.61–4.68) | 0.32 |
| Forniceal conjunctiva | 24 (30.4) | 9 (28.1) | 15 (31.9) | 0.84 (0.31–2.24) | 0.72 |
| Palpebral conjunctiva | 31 (39.2) | 19 (59.4) | 12 (25.5) | 4.26 (1.63–11.17) | <0.01* |
| cT category, AJCC 8th edition | |||||
| T1 + T2 | 37 (46.8) | 3 (9.4) | 34 (72.3) | ref | |
| T3 | 42 (53.2) | 29 (90.6) | 13 (27.7) | 25.28 (6.56–97.49) | <0.01* |
| Breslow thickness (mm) | |||||
| Mean (range) | 5.0 (0.2–16.1) | 6.3 (0.2–16.1) | 4.0 (0.6–14.1) | 1.19 (1.01–1.39) | 0.03* |
| Unknown | 20 (25.3) | 5 (15.6) | 15 (31.9) | ||
| pT category | |||||
| T1 + T2 | 23 (29.1) | 4 (12.5) | 19 (40.4) | ref | |
| T3 | 36 (45.6) | 23 (71.9) | 13 (27.7) | 11.80 (2.94–47.41) | <0.01* |
| Unknown | 20 (25.3) | 5 (15.6) | 15 (31.9) | ||
| Ulceration | |||||
| Absent | 35 (44.3) | 15 (50) | 20(40.4) | ref | |
| Present | 23 (29.1) | 11 (34.4) | 12 (25.5) | 1.03 (0.36–2.98) | 0.96 |
| Unknown | 21 (26.6) | 6 (18.8) | 15 (31.9) | ||
| Predominant cytology | |||||
| Epithelial | 35 (44.3) | 16 (50) | 19(40.4) | ref | |
| Spindle | 13 (15.2) | 6 (18.8) | 7 (14.9) | 1.02 (0.28–3.65) | 0.98 |
| Mixed | 10 (11.4) | 4 (12.5) | 6 (12.8) | 0.79 (0.19–3.31) | 0.75 |
| Unknown | 21 (26.6) | 6 (18.8) | 15 (31.9) | ||
| Mitotic rate (/mm2) | |||||
| Median (range) | 8 (0–46) | 8 (0–40) | 8 (0-46) | 1.01 (0.96–1.06) | 0.63 |
| Unknown | 21 (26.6) | 6 (18.8) | 15 (31.9) | ||
| Microscopic satellitosis | |||||
| Absent | 54 (68.4) | 24 (75.0) | 30(63.8) | ref | |
| Present | 4 (5.1) | 2 (6.3) | 2 (4.3) | 1.25 (0.16–9.54) | 0.83 |
| Unknown | 21 (26.6) | 6 (18.8) | 15 (31.9) | ||
| Regression | |||||
| Absent | 46 (55.7) | 22 (68.8) | 24 (46.8) | ref | |
| Present | 12 (15.2) | 4 (12.5) | 8 (17.0) | 0.55(0.14–2.07) | 0.37 |
| Unknown | 21 (26.6) | 6 (18.8) | 15 (31.9) | ||
| Tumour infiltrating lymphocyte (TIL) | |||||
| Absent | 10 (13.9) | 4 (15.6) | 6 (12.8) | ref | |
| Nonbrisk | 42 (50.6) | 19 (59.4) | 23 (44.7) | 1.24 (0.30-5.04) | 0.77 |
| Brisk | 6 (7.6) | 3 (9.4) | 3 (6.4) | 1.50 (0.20–11.54) | 0.70 |
| Unknown | 21 (26.6) | 6 (18.8) | 15 (31.9) | ||
| Perineural invasion | |||||
| No | 52 (65.8) | 24 (75.0) | 28 (59.6) | ref | |
| Yes | 6 (6.3) | 2 (6.3) | 4 (8.5) | 0.54 (0.09–3.21) | 0.50 |
| Unknown | 21 (26.6) | 6 (18.8) | 15 (31.9) | ||
| Vascular invasion | |||||
| No | 48 (59.5) | 21 (65.6) | 27 (57.4) | ref | |
| Yes | 10 (12.7) | 5 (15.6) | 5 (10.6) | 1.29 (0.33–5.03) | 0.72 |
| Unknown | 21 (26.6) | 6 (18.8) | 15 (31.9) | ||
| Multiple relapses | |||||
| Yes | 19 (24.1) | 11 (34.4) | 8 (17.0) | 2.55 (0.89–7.33) | 0.08 |
| Primary or recurrent disease at presentation | |||||
| Primary | 49 (62.0) | 18 (56.3) | 31 (66.0) | ref | |
| Recurrent | 30 (38.0) | 14 (43.8) | 16 (34.0) | 1.51 (0.60–3.79) | 0.38 |
| Regional metastasis at presentation | |||||
| No | 75 (94.9) | 30 (93.8) | 45 (95.7) | ref | |
| Yes | 4 (5.1) | 2 (6.3) | 2 (4.3) | 1.50 (0.20–11.24) | 0.69 |
| Distant metastasis at presentation | |||||
| No | 79 (100) | 32 (100) | 47 (100) | NA | NA |
| Yes | 0 (0) | 0 (0) | 0 (0) |
Data are presented as number of patients (%) or median (interquartile range).
OR odds ratio, ref reference variable.
*Statistically significant.