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. 2023 Jul 24;13:11968. doi: 10.1038/s41598-023-39212-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Macroscopic pathology and the scheme of experimental design. Representative photos of the macroscopic pathology of subcutaneous tissues in diabetic mice at 6 weeks after pretreatment in the GHNF (A) and control (B) groups are shown. The capsule surrounding the silicon spacer in the GHNF group appeared to be thicker than that in the control group (black arrows). No bleeding or inflammation were observed in either group. The scheme of experimental design (C).